If is from dried tuber roots of Pseudostellaria heterophylla (Miq.) Pax, with extraction, purification and freeze-drying technology, contains high quantity of Heterophyllin B.

Pseudostellaria heterophylla is one famous traditional Chinese Medicine. Taste sweet, slightly bitter, flat. It has the effect of nourishing qi and invigorating spleen, nourishing body and moistening lung. Used for spleen deficiency body tiredness, loss of appetite, weakness after illness, deficiency of qi and Yin, spontaneous sweating thirst, dry lung cough.

Pseudostellaria heterophylla contains a variety of polysaccharides, cyclic peptides (the unique components of Pseudostellaria heterophylla), amino acids, saponins, phenolic acids, etc., which have nourishing and protecting effects on skin and hair.

Heterophyllin B (HB), a cyclic octapeptide composed of L-type encoded amino acids, is a characteristic component of the cyclic peptides extracted from Pseudostellaria heterophylla.

Through the research of network pharmacology and molecular docking technology, we found the core target molecules of HB with anti-aging and anti-irritation are STAT3, MMP9, NFKB1 & SIRT1, etc.

Validation of anti-aging direction of network pharmacology:

- Enhanced the viability of fibroblasts

- Enhanced the expression of longevity protein SIRT1

- Inhibition of STAT3 expression

- Inhibition of lipofuscin aggregation in C.elegans

- Inhibition of heat stress in C.elegans

- Inhibition of oxidative stress in C.elegans

Keytrum can also provide the liquid form of Pseudostellaria heterophyllam extract.